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Journal o Chemistry Science
In order to generate compounds with certain inherent features for specified applications, novel preparative procedures for silver carbene complexes have been developed, and previous ones have been improved. The field of medicine is one of the key application areas that has expanded quickly and where carbene complexes are becoming more and more relevant. Much synthetic research has been accompanied by complex theoretical computations. This critical evaluation covers these elements.
The potential of artificial silver N-heterocyclic carbene complexes as drugs is examined in this article. Following the synthesis of new carbene species from the 5,6-dimethyl-1H-benzo[d]imidazole-based compound, metal complexes have been produced for this use. A number of identification techniques were used to study the chemical structures of these carbenes and metal complexes, including melting point analysis, conductivity, 1H and 13C-NMR, LC-Mass, FTIR, TGA, and UV-vis spectrophotometry. The main feature that makes these metal complexes different is the tail, which is attached to the nitrogen group. Antimicrobial and antibacterial properties of silver(I)-N-Heterocyclic complexes were investigated against Gram-positive and Gram-negative bacteria as well as fungi using the disk diffusion method. In addition, the cytotoxicity properties of this silver(I)-N-Heterocyclic complex were also tested.